Evaluation of the Disintegration Properties of Khaya senegalensis Gum Using Paracetamol Tablets

Abstract

Background: Disintegrants are essential in the formulation of solid dosage forms such as tablets because they aid in the release of the active drug for therapeutic action. Disintegrating agents such as starch are currently posing challenges such as tablet softening and slow disintegration. In the quest for alternatives that are cheaper, readily available and possessing same or better disintegrating property, Khaya senegalensis gum was considered. Currently, there is no available literature pertaining to its disintegrating property. Objective: To investigate the disintegrating properties of Khaya senegalensis gum using paracetamol tablets. Methods: K. senegalensis gum was obtained by making an incision on the stem bark of the mahogany tree. The dried purified K. senegalensis gum was employed in the formulation of granule I whiles Tragacanth gum was used in formulating granule II using the wet granulation technique. The flow properties of both granules were subsequently determined and compared. Paracetamol tablets were then produced with the formulated granules I and II. Friability, hardness, weight uniformity and disintegration testing were performed on the paracetamol tablets formulated with both granules. Results: The results showed granule I had a better flowability with angle of repose 31.63°C, Hausner’s ratio 1.24 and Carr’s index 19.57 as compared to granule II with angle of repose 34.72°C, Hausner’s ratio 1.31 and Carr’s index 23.84. The study also revealed, paracetamol tablets formulated with granule I (K. senegalensis gum) passed the hardness test (6.57 Kg.f), disintegration time (2.44 min), weight uniformity test (2.2% standard deviation) and friability test (0.69%). Paracetamol tablets formulated with granule II (Tragacanth gum) also passed the hardness test (8.20 Kg.f), disintegration time (7.69 min), weight uniformity test (1.6% standard deviation) and friability test (0.86%). Conclusion: Khaya senegalensis gum can therefore be explored as an alternative disintegrant in the formulation of paracetamol tablets for improved bioavailability.