Antineoplastic Activities of Grape Seed Proanthocyanidin Extract against Ehrlich Solid Tumor Bearing Mice Induced Alterations in AFP, CEA, TNF-α and DNA Damage

Abstract

Background and Objective: Cancer is initiated due to abnormalities in the DNA of the affected cells leading to an extra mass of tissue termed a tumor. Breast cancer is the most public cancer amongst women world-wide. The present work is designed to investigate the ameliorating potential effects of grape seed proanthocyanidin extract (GSPE) in inhibition of Ehrlich cells growth and tumor development as a model for breast cancer. Also; the present work is designed to investigate the effect of GSPE on the changes in the levels of AFP, CEA, TNF-α and hematological alterations, and DNA damage examination on Ehrilch solid tumor (EST) bearing mice. Materials and Methods: A total of 40 female mice were evenly distributed amongst four groups (G1, control group; G2, GSPE group; G3, EST group; IV, EST+GSPE group). Results: Results revealed increased incidences of tumor growth in the untreated EST group, along with elevated levels of serum AFP, CEA, TNF-α, WBCs, platelets and DNA damage and an associated reduction in RBCs and Hb%. Treatment of EST with GSPE (EST+GSPE) modulates and improved these changes in CBC, tumor markers and DNA damage as compared to mice bearing EST. Conclusion: This finding calls for more investigation on the benefits of grape seed proanthocyanidin extract (GSPE) as antineoplastic activity on other tumors as Ehrlich ascites carcinoma or cancer.