Effects of Aqueous Leaves Extracts of Individual and Polyherbal Formulated Ointments in Demonstration of Elastic Fibres on Wound Healing of Wounded Skin of Wistar Rats

Abstract

Wound defined as a loss or breaking of epithelial cellular. Wound healing is a complex process that is dependent on several factors that may hasten or affect the process of wound healing activity. The aim of the study was to assess the effects of aqueous leaves extract of individual and polyherbal formulated ointments in wounded skin of wistar rats. Total of 45 healthy wistar rats were divided into 9 groups, with 5 rats in each. Group A negative control, wounded no treatment, group B positive control, wounded and treated with standard drug, group C test wounded treated with aqueous extract of A nilotica only, group D test wounded treated with aqueous leaves extract of A. vera only, group E test group wounded and treated with aqueous leaves extract of C. procera only, group F test wounded treated with combinations of aqueous leaves extract of A. nilotica and A. vera, group G wounded treated with combinations of aqueous leaf extract of A. nilotica and C. procera, the group H wounded treated with aqueous leaves extract of aloe vera and C. procera and group I test wounded treated with aqueous leaves extract of  polyherbal formulation of A. nilotica, A. vera and C. procera. The result of the study showed that extracts of A. nilotica has better physical properties than other extracts, The aqueous leaves extract the Acacia nilotica, Aloe vera and Calotropis procera shows very good physical characteristics and presence of secondary metabolites that possessed wound healing effect. In conclusion the research showed elastic fibres deposition in groups treated with aqueous leaves extract of Acacia nilotica formulated ointments and in combination of the three extracts of the studied sections.