Dielectric Blood Coagulometry as a Novel Coagulation Test
Sahoko Chiba, Ken Uchibori, Takasato Fujiwara, Tomoyuki Ogata, Shuta Yamauchi, Tuyoshi Shirai, Masahiro Masuo, Tsukasa Okamoto, Tomoya Tateishi, Haruhiko Furusawa, Toshihide Fujie, Hiroyuki Sakashita, Kimitake Tsuchiya, Meiyo Tamaoka, Yasunari Miyazaki, Naohiko Inase, Yuki Sumi
Journal of Scientific Research and Reports · pp. 180–188 · Published 10 Oct 2014
10.9734/JSRR/2015/10674Abstract
Background: Dielectric blood coagulometry (DBCM) has been presented as a new test for estimating the risk of venous thromboembolism (VTE) by measuring the permittivity change associated with blood coagulation. Yet no earlier studies have investigated the clinical utility of DBCM. Objective: We aimed to estimate the clinical utilities of DBCM. Methods: Our group prospectively measured DCT, the clotting time estimated by DBCM, in 192 inpatients at the Department of Respiratory Medicine of Tokyo Medical and Dental University Hospital between May 2011 and January 2013. We also measured in 28 healthy volunteers as control group. Additionally, other laboratory findings were evaluated for both patients and controls. Results: The normal range of DCT was estimated at between 21.0 and 54.8 minutes based on measurements of healthy volunteer controls. Coagulation was significantly accelerated in patients with interstitial pneumonitis, lung cancer, chronic obstructive pulmonary diseases and sleep apnea syndrome, when measured by DBCM. There was little correlation between DCT and conventional coagulation test results. Conclusion: DBCM is a novel tool for estimating blood coagulation and may be useful for identifying patients at high risk of thrombosis. However a single DCT measurement would be insufficient for a definite diagnosis of thrombosis. Further long-term observation is needed to evaluate the usefulness of DBCM.
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