The Association of Lipids, Lipoproteins and Apolipoproteins Patterns with Cardiovascular Disease in Patients with Type 2 Diabetes
Journal of Advances in Medicine and Medical Research · pp. 1–8 · Published 10 Aug 2016
10.9734/BJMMR/2016/28170Abstract
Diabetes mellitus is a chronic metabolic disease that is common in nearly all countries. Patients with type 2 diabetes have a two- four fold increased risk of developing cardiovascular disease (CVD) relative to nondiabetic individuals. Herein, in this systematic review we briefly explored the pathophysiology of lipids, lipoproteins, and apolipoproteins patterns in type 2 diabetics and its association to macrovascular disease mainly CVD. Data from clinical and experimental studies reported abnormalities in concentrations of lipids, lipoproteins, and apolipoproteins in type 2 diabetics and that correlated with the progression of CVD. The disturbance in concentrations of lipid profile contributes in the atherogenesis in patients with type 2 diabetes though multiple mechanisms. Therefore, targeting and management of circulating lipids in type 2 diabetics can provide opportunity to reduce CVD morbidity and mortality.
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