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Research Article Open access CC BY 4.0

Bis(4,6-dimethyl-2-pyridylseleno)zinc 3,3’-dicyanide, A Potent Antifungal Agent

V. H. Shah, A. A. Zohri, P. K. Talpara, P. A. Sangala, M. A. Abdelazim

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–4 · Published 22 Apr 2019

10.9734/jamps/2019/v20i230107

Abstract

A novel zinc chelate of 3-cyano-4,6-dimethyl-2(1H)-selenone pyridine was synthesized and its structure was confirmed on the basis IR, 1H NMR, 13C NMR spectral analyses and TOF mass spectrometry. Biological screening against Candida glabrata reveals a greater antifungal activity of the zinc chelate as compared to the fluconazole reference drug.

Synthesis bis(4,6-dimethyl-2-pyridylseleno)zinc 3,3’-dicyanide fluconazole antifungal activity Candida glabrata

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