Generalization of High-Throughput Experimentation in Organic Chemistry: Case Study on the Flortaucipir Synthesis
Gaëtan Ossard, Milene Macedo Hornink, Sabrina Lebrequier, David-Alexandre Buisson, Jean-Christophe Cintrat, Eugénie Romero
Organics · pp. 50–50 · Published 5 Nov 2025
10.3390/org6040050Abstract
High-Throughput Experimentation has undergone an outstanding evolution in the past two decades and has proven to be a game-changer in the acceleration of reaction discovery and optimization. Despite a good implementation in the pharmaceutical industry and a demonstrated accessibility to the technology, the generalization of High-Throughput Experimentation as a standard method for optimizing reactions is not yet observed. The perspective aims at discussing the necessity of generalizing such technologies, supported by the case study: the optimization by High-Throughput Experimentation of a key step in the synthesis of Flortaucipir, an FDA-approved imaging agent for Alzheimer’s diagnosis.
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