Evaluation of Antidiabetic and Hypolipidemic Efficacy of Various Fractions of Heartwood of Pterocarpus marsupium (Fabaceae) on Alloxan Induced Diabetic Rats

Abstract

Aim: The objective of the present work is to study the antidiabetic and hypolipidemic effect of different fractions of heart wood of Pterocarpus marsupium in alloxan induced diabetic rats. Methodology: Diabetes was induced by administering alloxan dissolved in saline (65 mg/kg body wt.), while the normal control group was given the vehicle (propylene glycol). After seven days of stabilization period, blood was drawn and the plasma was estimated for blood glucose. Animals which had more than 200 mg/dl of blood glucose were included in the study. Blood glucose estimation was done on Day 1, 15 and 30. Estimation of lipid profile was done on day 30 only. Diabetes induced animals were randomly assigned into different groups. Results: Alloxan induced diabetic rats treated with various extracts (75 mg/kg body wt.) showed marked hypoglycemia, hypo-triglyceridemia and hypocholesterolemia at the end of the study period. Conclusion: Thus the present study suggested the potential use of heart wood of P. marsupium in treating diabetes as well as related cardiovascular complications.