A Review on Resealed Erythrocytes as a Novel Drug Delivery System

Abstract

The most prevalent form of blood cell is the red blood cell. RBCs resemble biconcave discs with a 7.8 mm diameter and a thickness of about 2.2 mm. There are two ways that erythrocytes can be used as carriers: Targeting a specific tissue or organ, for continuous or extended medication release. For the delivery of medications, various kinds of mammalian erythrocytes have been employed. There are numerous techniques, including the hypo-osmotic method, the dilution method, the dialysis method, the press well method, the isotonic osmotic lyses, the electrical breakdown method, the endocytosis method, the membrane perturbation method, the normal transport method, and the lipid fusion method. After erythrocytes have been loaded with the therapeutic drug, carrier cells are subjected to physical, cellular, and biological examinations. Several invitro tests have shown the value of carrier RBCs. The RBC mediated microinjection that occurs most frequently invitro. Today, a wide range of uses for resealed erythrocytes as medication carriers, enzyme replacement treatment, etc. have been proposed.