Preliminary Study of Hypoglycemic Effect of Locust Bean (Parkia biglobosa) on Wistar Albino Rat
O. J. Sule, J. Godwin, A. R. Abdu
Journal of Scientific Research and Reports · pp. 467–472 · Published 5 Nov 2014
10.9734/JSRR/2015/8044Abstract
The hypoglycemic effect of locust bean (parkia biglobosa) in Wistar Albino rats was assessed. Blood glucose concentrations were determined for each group using glucose oxidase method. Group A (Control) received growers mash, while groups B,C and D received 20%, 40% and 50% of locust bean respectively for 21 days. There was significant decrease in the blood glucose concentrations of rats in groups C (5.5±0.03) and D (5.1±0.03) when compared with control (5.8±0.07mM/L), p≤0.05 on the 7th day of the treatments. However rats in group B only showed significant decrease in blood glucose concentrations on the 14th and 21st days (5.4±0.03mM/L and 5.3±0.03mM/L) respectively, when compared with the control (5.8±0.04mM/L and 5.8±0.06mM/L) respectively, p≤0.05. The validation of the hypoglycemic activity of locust bean suggest that it may be useful in the treatment of diabetes mellitus.
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