Skip to content
Research Article Open access CC BY 4.0

Integrating Corneal Collagen Crosslinking with Refractive Procedures (LASIK and PRK): A Comprehensive Review

Neelima Balakrishnan, Prabhu Vijayaraghavan, Vandhana Sundaram, Jagadeesh Kumar Reddy

Ophthalmology Research: An International Journal · pp. 1–8 · Published 15 Jan 2025

10.9734/or/2025/v20i1446

Abstract

Corneal collagen crosslinking is primarily carried out as a treatment modality for the management of corneal ectasias such as keratoconus, keratoglobus, pellucid marginal degeneration etc, as well as for the management of post refractive surgery corneal ectasias. However, it has evolved into a tool to strengthen the cornea in patients with borderline topography, who desire spectacle independence. This combined technique aims to enhance corneal strength and stability while maintaining visual acuity. However, careful patient selection, precise surgical planning, and understanding the biomechanical effects of crosslinking on the refractive outcome are essential to optimize the results. This article reviews the current evidence, risks, and considerations of simultaneous corneal collagen crosslinking and refractive surgery, highlighting its role in modern corneal and refractive surgery practices.

Corneal collagen corneal ectasias treatment refractive surgery

References (13)

  1. 1 Riboflavin/ultraviolet-a–induced collagen crosslinking for the treatment of keratoconus [DOI]
  2. 2 Iatrogenic Keratectasia after Laser in situ Keratomileusis [DOI]
  3. 3 Mechanisms of Corneal Tissue Cross-linking in Response to Treatment with Topical Riboflavin and Long-Wavelength Ultraviolet Radiation (UVA) [DOI]
  4. 4 Ectasia risk factors in refractive surgery [DOI]
  5. 5 A 10-Year Prospective Audit of LASIK Outcomes for Myopia in 37932 Eyes at a Single Institution in Asia [DOI]
  6. 6 Corneal ectasia after myopic laser in situ keratomileusis: a long-term study [DOI]
  7. 7 Incidence, Outcomes, and Risk Factors for Retreatment After Wavefront-optimized Ablations With PRK and LASIK [DOI]
  8. 8 Superficial corneal crosslinking during laser in situ keratomileusis [DOI]
  9. 9 Comparative analysis of safety and efficacy of photorefractive keratectomy versus photorefractive keratectomy combined with crosslinking [DOI]
  10. 10 Risk Assessment for Corneal Ectasia following Photorefractive Keratectomy [DOI]
  11. 11 Outcomes of simultaneous photorefractive keratectomy and collagen crosslinking [DOI]
  12. 12 Corneal Ectasia After LASIK Combined With Prophylactic Corneal Cross-linking [DOI]
  13. 13 Rate of ectasia and incidence of irregular topography in patients with unidentified preoperative risk factors undergoing femtosecond laser-assisted LASIK

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

28

Page views

0

PDF downloads

11

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.