Skip to content
Research Article Open access CC BY 4.0

One Pot Synthesis of Tetra-substituted Imidazole Derivatives by Condensation Reaction Using Zeolite H- ZSM 22 as a Heterogeneous Solid Acid Catalyst

Sami Ullah Bhat, Rawoof Ahmad Naikoo, Radha Tomar

International Research Journal of Pure and Applied Chemistry · pp. 1–10 · Published 11 Jan 2016

10.9734/IRJPAC/2016/21443

Abstract

The present work deals with the synthesis of tetra substituted imidazoles using environmentally benign and green catalyst H-ZSM-22. The synthesized catalyst was characterized by FTIR (Fourier-transform infrared spectroscopy), XRD and the products by FTIR and 1HNMR. H-ZSM-22 has been used as an efficient catalyst for an improved and rapid synthesis of 1,2,4,5 tetra substituted imidazoles derivatives using reactants: Benzil, Aldehydes, Amines and Ammonium acetate having excellent yield under solvent conditions. Different derivatives of aldehyde have been used in this reaction. For all the synthesized derivatives, ambient reaction time was found to be of 15-30 min. The main advantage of this reaction is small reaction time, high purity yield, easy work up and pollution free.  

H-ZSM-22 one-pot synthesis multi-component reaction tetra-substituted imidazoles

Cited by 11

Development of ZSM-22/Polyethersulfone Membrane for Effective Salt Rejection

Nyiko M. Chauke, Richard M. Moutloali, James Ramontja · Polymers · 2020

Solid acids for the synthesis of biologically active heterocycles

Manisha Mishra, Béla Török · Green Synthetic Approaches for Biologically Relevant Heterocycles · 2021

Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1 H ‐Imidazole Derivatives: State of the Art

Renzo Rossi, Gaetano Angelici, Gianluca Casotti · Advanced Synthesis & Catalysis · 2019

An efficient green protocol for the synthesis of tetra-substituted imidazoles catalyzed by zeolite BEA: effect of surface acidity and polarity of zeolite

Jenifer J. Gabla, Sunil R. Mistry, Kalpana C. Maheria · Catal. Sci. Technol. · 2017

Contemporary Progress in the Synthetic Strategies of Imidazole and its Biological Activities

Jay Soni, Ayushi Sethiya, Nusrat Sahiba · Current Organic Synthesis · 2020

Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review

Drashti G. Daraji, Neelam P. Prajapati, Hitesh D. Patel · Journal of Heterocyclic Chemistry · 2019

Tuning Anticancer Properties via Electron Distribution: Inducing Apoptosis Through Downregulation of Reactive Oxygen Species and Docking Studies on Bcl‐2 Protein by a 2,4,5‐Trisubstituted‐1H‐Imidazole Compound

Hemanathan Elango, Subhabrata Guha, Suganya Ganesan · ChemistrySelect · 2025

Electrochromic windows based on luminescent acrylate/ionosilicas

Daniela Pinheiro, Rui F. P. Pereira, Alexandra Gonçalves · Journal of Sol-Gel Science and Technology · 2024

Various synthesis and biological evaluation of some tri -tetra-substituted imidazoles derivatives: A review

Abdeljalil Hamdi, Walid Daoudi, Mohamed Aaddouz · Heliyon · 2024

Ag–TiO2 nanocomposite-catalyzed one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles: a green and benign approach

Soghra Alipour, Seyed Mohammad Vahdat, Fereshteh Chekin · Journal of the Iranian Chemical Society · 2021

Related research

Article metrics

Real usage data collected on this platform.

0

Page views

0

PDF downloads

0

Outbound clicks

11

Citations

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

No views recorded yet.

Traffic sources

Referring site, by host.

No traffic recorded yet.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.