Assessment of Renal Functions among Sudanese Patients with Acute Lymphoblastic Leukemia's Receiving Chemotherapy in Radiation and Isotopes Center of Khartoum (RICK), Sudan

Abstract

Background: A wide array of disturbances in electrolyte equilibrium is commonly seen in patients with acute leukemia (AL). These abnormalities present a potential hazard in these patients, as that of enhancing the cardio-toxic effects of certain chemotherapeutic regimens. Materials and Methods: This study was designed as interventional study, which includes 50 samples, the data was collected form hospital archives, include both male and female (the males is 24 with 48% while the rests 26 is females with 52%), from different area in Sudan (east is 2%, west is 64%, north is 10%, south is 12%, and center is 12%), have different classification of Acute Lymphoblastic Leukemia's (L1 is 17 with 34%, L2 is 27 with 54% and L3 is 6 with 12%). Carried out in Radiation and Isotopes Center of Khartoum in Khartoum state, during the period from February 2020 to January 2021, and the obtained data were analyzed by SPSS. Results: The result of this study showed that there was insignificant difference (p 0.05) in the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, and magnesium in the study groups before and after treatment, and significant increase in the serum level of potassium in the study groups after treatment p. value of 0.007, the mean of serum level of potassium before and after treatment is 2.688 and 3.702 respectively. And insignificant difference (p 0.05) in the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, potassium and magnesium in the study groups before and after treatment according to gender and FAB classification. Conclusion: The study conclude that the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, and magnesium was not affected by treatment, but the potassium is increased after treatment. And the gender and classification of Acute Lymphoblastic Leukemia's have insignificant effect on the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, potassium and magnesium.