Hepato-Renal-Curative Effect of the Herbal Supplement of Aloe vera Linn Gel versus Moringa oleifera on Acetaminophen-Induced Damage on the Liver and Kidney of Wistar Rats (Rattus novergicus)

Abstract

Background: Acetaminophen (APAP, paracetamol) is the most frequently used over-the counter analgesic and antipyretic drug. Conversely, its overdose leads to both liver and kidney damage. Several scientific reports have focused majorly on protective effects of medicinal plants on APAP –induced hepato-renal-toxicity. actually, there is a dearth of work on the hepato-renal-curative effects of the herbal drugs supplements on APAP induced toxicity. Aims: In the present study, Aloe vera (ALOV) gel versus Moringa oleifera (MORN) leaf supplement effects was evaluated curatively against Acetaminophen (APAP) induced hepato- renal-toxicity.  Study Design:  This study was an experimental study in the Animal House of the Department of Pharmacology University of Port Harcourt. The work lasted for 7 days. Methodology: Twenty adult wistar rats weighing 185-220 g were divided into four (4) groups of five (5) animals each and treated orally as follows: group 1(normal control) received distilled water (7days), group 2 received 1 g/kg acetaminophen (APAP) (2 days), whereas group 3-4  received APAP (2 days) followed by 500 mg/kg of ALOV and MORN supplements respectively for 5 days. At the end of the experiment, animals from different groups were anaesthesized, the liver and kidney tissues were dissected and blood collected subjected to different biochemical, antioxidants, and histopathological test. Statistical Analysis: was done using One-Way Anova followed by Tukey’s Post-hoc Test. Results: APAP caused significant (P<0.05) decrease in creatinine with significant (P<0.01) increase and decrease in liver enzymes and renal catalase levels respectively in relation to normal control. Treatment of rats with the ALOV and MORN supplements attenuated the elevated liver and kidney biochemistry as well as improved histopathological alterations by APAP treatment. Conclusion: The supplements demonstrated restorative ability. MORN and ALOV supplements extract can be suggested as a convincing remedy against APAP-induced hepato-renal-toxicity.