Effect of Hydrolyzable Tannins of Euphorbia Plants on the Rat Antioxidant System of under Oxidative Stress

Abstract

Aim: Study of the effect of hydrolyzable tannins isolated from Euphorbia plants on alloxan-induced OS under in vivo conditions. Methodology: Polyphenols were isolated from Euphorbia plants using an extraction method, after which the effect of these polyphenols on malondialdehyde (MDA) and glutathione reductase (GR) activity under oxidative stress in rats was determined in vivo. Results: The data obtained show that the studied hydrolyzable tannins reduce the amount of MDA in organs and tissues to the control level under alloxan-induced OS conditions. It was also found that polyphenols 3GHG, 1GHG and geraniin restore GR activity, and 2DGG had virtually no effect on the restoration of enzyme activity in the blood plasma and pancreas under OS conditions. However, the studied hydrolyzable tannins provide feebly expressed influence on the restoration of GR activity in the liver of rats under OS conditions. Conclusions: Thus, these hydrolyzed tannins exhibit strong antioxidant properties when acting on the amount of MDA, but when the GR activity is restored, their activity is weakly expressed.