Effect of Imidacloprid Exposure on Sperm Count and Morphology in Swiss Albino Mice

Abstract

Neonicotinoid insecticides are thought to be a good substitute for organophosphate pesticides, although some data suggest that they have negative effects on male reproductive health. This study investigates the effects of Imidacloprid (IMI) exposure on sperm parameters- including sperm count, motility, viability, and morphology in male Albino mice. Male mice were orally administered four significant doses of imidacloprid (Control group, control vehicle, low dose -25mg/kg b.wt., high dose 50mg/kg b.wt.) for an over-specified period, to evaluate sperm parameters. Results revealed a significant reduction in sperm count, sperm mobility and viability, and an increase in percentage of sperm abnormalities in treated groups as compared to controls in male Mus musculus following IMI exposure. These findings highlight the potential reproductive risks associated with IMI that may impair male fertility by inducing sperm toxicity. These findings suggest that imidacloprid exposure may impair male fertility by inducing sperm toxicity. Further research is essential to investigate the mechanisms underlying these reproductive alterations and investigate the broader implications for environmental and human health.