Evaluation of Anti-inflammatory Activities of Erythrococca anomala Aqueous and Ethanolic Extracts from Leaves in Rat

Abstract

Aims: This study was therefore aimed to evaluate potential anti-inflammatory activity of Aqueous and Ethanolic extracts of Erythrococca anomala leaves (Euphorbiaceae) and to determine the most active extract in rat. Study Design: Erythrococca anomala leaves were collected from Yakasse-Me area in the Department of Adzopé (Côte d’Ivoire). The plant was identified and authenticated by the Botanic Laboratory, University Felix Houphouet Boigny, Cocody (Côte d’Ivoire). Place and Duration of Study: Analysis on the plant samples was done in pharmacodynamic Biochemistry Laboratory, University Felix Houphouet Boigny, the Laboratory of Organic Chemistry and Natural Substances, University Felix Houphouet Boigny and the Laboratory of Pharmacology, University Felix Houphouet Boigny between April and May 2016. Methodology: The anti-inflammatory activities were investigated by utilizing carrageenan induced paw edema and CRP (C-reactive protein) concentration in rat. These extracts were administrated intraperitonealy at different doses (100 and 200 mg/kg body weight) to rats. Results: Both extracts with 200 mg/kg.b.w. showed a good anti-inflammatory activity compared to Diclofenac (25 mg/kg). This study also showed an increased CRP concentration (p<0.05). However, the inflammation inhibition is raised more than 26.25% with the aqueous extract compared to ethanolic extract. Conclusion: This study showed that aqueous and ethanolic extracts of Erythrococca anomala leaves possess a potential anti-inflammatory properties. However, this anti-inflammatory activity is more raised with aqueous extract and seems to have the most active extract. So aqueous and ethanolic extracts can be utilized for therapeutic purposes.