Advancements in Precision Medicine for Myelodysplastic Neoplasms and Acute Myeloid Leukemia: A Review on Genomics to Targeted Therapies
Eric Emmanuel U, Eberechukwu G C, Boloya V. E
Asian Oncology Research Journal · pp. 28–33 · Published 16 Jan 2026
10.9734/aorj/2026/v9i1123Abstract
Myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML) are clonal hematopoietic disorders characterized by ineffective hematopoiesis and rapid proliferation of abnormal myeloid cells, respectively. Recent advances in molecular biology have significantly enhanced our understanding of the pathogenesis of MDS and AML, leading to improved diagnostic methods and novel therapeutic strategies. This review highlights the latest developments in genetic and epigenetic alterations, the role of the bone marrow microenvironment, advancements in diagnostics, targeted therapies, immunotherapies, and personalized medicine approaches in MDS and AML. Challenges and future directions are also discussed to provide a comprehensive overview of the current landscape and potential advancements in the management of these hematologic malignancies.
Cited by 0
No indexed citations yet.
Related research
- Impact of DNMT3A Gene Mutation on Response of Acute Myeloid Leukemia Patients to Induction Therapy — shares topic coverage
- Serum Leptin and Adiponectin Levels in de Novo Acute Myeloid Leukemia Patients: Correlation with Clinical Characteristics — shares topic coverage
- Venetoclax First Cycle Treatment in a Case of Severe AML FAB M2 and COVID-19 Pneumoniae: A Rare Clinical Scenario — shares topic coverage
- Frequency of Induction-Related Mortality in Patients of Acute Myeloid Leukemia - Experience from a Resource Limited Country — shares topic coverage
- Spectrum of Complications in Patients of Acute Leukemia- A Regional Study from Pgims, Rohtak — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.