Immunohistochemical Expression of 40S Ribosomal Protein SA and Fibronectin-1 in Breast Cancer Tissues from Sudanese Patients

Abstract

Laminin-1 receptor (40S ribosomal protein SA) and fibronectin-1 belong to the extracellular matrix (ECM) proteins which are involved in cell adhesion, migration and growth. This study was implemented for the purpose of investigating the expression of 40S ribosomal protein SA and fibronoectin-1 in breast cancer tissues from Sudanese patients. One hundred and eight cancerous breast tissues and 42 normal breast tissues were involved in this study from the Histopathology laboratory of the Radiotherapy and Isotopes Center in Khartoum (RICK). The expression of 40S ribosomal protein SA and fibronectin-1 was investigated using the immunohistochemistry (IHC) Technique. The 40S ribosomal protein SA was positively expressed in 101 cancerous tissues (93.5%) compared to 15 normal breast tissues (35.7%). The fibronectin-1 staining was positive in 92 cancerous tissues (85.2%) compared to 14 normal breast tissues (33.3%). The expression of the laminin-1 receptor and fibronectin-1 together was positive in 88 cancerous tissues (81.5%) and the two were negative in 3 cancerous tissues (2.8%). The 40S ribosomal protein SA and fibronectin-1 together were positive in 6 normal breast tissues (14.3%) compared to 18 negative normal tissues (42.9%). When the mean ranks of the 40S ribosomal protein SA and the fibronectin-1 in the cancerous tissues were compared to their mean ranks in the normal tissues using the Mann-Whitney test, their differences were significant (p ≤ 0.000). The collective expression of fibronectin-1and 40S ribosomal protein SA may be used as targets in trial for the treatment of breast cancer since their expression was positive in 81.5% of the cancerous tissues compared 14.3% of the normal tissues.