Herbology, Antibacterial and Antihaemorrhagic Effect of Allium sativum Linn (Lilliaceae) Extracts against Bacterial Meningitis Pathogens

Abstract

Bacterial Meningitis pathogen (BMP) causes cellular hemorrhagic sepsis, metabolic, endocrine and neurologic disorders in human systems. This burden of the disease is highest in the developing countries and especially in the immunity compromised rural populations in Sub-Saharan Africa. The A. sativum bulb extracts (JEAS, EEAS and AEAS) contain valuable pharmacologically active principles for antihaemorrhagic and antibacterial properties against bacterial meningitis pathogens. It extracts were evaluated in Wistar rats to provide scientific basis for ethnomedicinal uses. The phytochemical screening was conducted using standard method prescribed. Anti-haemorrhagic activity was evaluated using sterilized blade lancet to cut 2mm long and 2mm deep in the rat groin model. The coagulative effects of time were significantly at P<0.05 reduced by the bulb extracts applied as compared to that of the control. The phytochemical screening revealed the presence of alkaloids, cardiac glycosides, carbohydrates, flavonoids, saponins, steroids and tannins. The result of this study revealed that A. sativum bulb extracts possessed good secondary metabolites with bioactive principles, biological and pharmacological functions. This provide scientific basis for the plant in the management of haemorrhagic sepsis and infectious disease.