Results of Allergological and Immunological Research in Patients with Polipoid Rhinosinusitis

Abstract

An exceptional role in protecting against pathogenic effects of various pathogenic and opportunistic microorganisms is played by immunoglobulins of the main classes. As our studies showed, before treatment, the IgG content in patients did not differ significantly from the control. The average IgA level in patients of both groups before surgery was slightly reduced (P> 0.05). Given the important role of IgA in protecting the body and, above all, the mucous membranes from infection, it can be concluded that such a disturbance of the biosynthesis of this class of immunoglobulin may be one of the reasons for the decrease in immune reactivity and frequent infectious processes. A sharp increase in serum IgE levels (239 ± 19.1 IU/ml) was observed in patients with eosinophilic polyposis rhinosinusitis, which we associate with an increase in IL-4 content and increased allergization of the body. This relative difference between patients of the two groups proves the need for appropriate diagnosis and treatment of chronic polyposis of rhinosinusitis. The aim of our research work was study allergically and immunologically results in patients with polipoidrhinosinusitis.