Hepatoprotective Effect of Origanum elongatum against Carbon Tetrachloride (CCl4) Induced Toxicity in Rats
B. Douhri, M. Idaomar, N. Skali Senhaji, A. Ennabili, J. Abrini
European Journal of Medicinal Plants · pp. 14–28 · Published 9 Oct 2013
10.9734/EJMP/2014/5132Abstract
Aims: This study was undertaken to investigate the potential effect of methanol extract of Origanum elongatum (OEME) given orally by gavage against intraperitoneal injection a single dose of Carbon tetrachloride (CCl4)(0.6 ml/kg) induced hepatotoxicity in rats. Study Design: Biochemical analysis, histological examination and in vivo study. Place and Duration of Study: Laboratory of Biology and health (Faculty of Science), between June 2012 and August 2012. Methodology: Hepatoprotective activity of OEME at four doses of 250 mg/kg, 500 mg/kg, 1000 mg/kg and 2000 mg/kg body weight. The degree of protection was estimated by biochemical analysis of serum liver biomarkers: AST, ALT, ALP and by liver histopathological examination. Results: The total phenolic content of OEME (83.61 ± 0.19 mg AGE / g extract) and total flavonoid content (10.85 ± 0.05 mg QE / g extract) were found significantly high. The present study showed that OEME was dose dependently decreased hepatic histopathological changes and serum liver biomarkers levels in CCl4 intoxicated rats. Conclusion: Data from present results revealed the hepatoprotection of OEME against hepatotoxic products or drugs.
Cited by 15
Narel Y. Paniagua-Zambrana, Rainer W. Bussmann, Olim K. Khojimatov · Ethnobotany of Mountain Regions · 2025
Omkulthom Al Kamaly, Aziz Drioiche, Firdaous Remok · Saudi Pharmaceutical Journal · 2024
Omar Belmehdi, Abdeltif El Harsal, Mourad Benmoussi · Biocatalysis and Agricultural Biotechnology · 2018
Soumaya Bourgou, Imtinen Ben Haj Jilani, Olfa Karous · Biology · 2021
Hesham R. El-Seedi, Hanen Najjaa, Rim Gatran · Beni-Suef University Journal of Basic and Applied Sciences · 2025
Balahbib Abdelaali, Naoual El Menyiy, Nasreddine El Omari · Evidence-Based Complementary and Alternative Medicine · 2021
Mouna Menakh, Saber Boutellaa, Djahida Mahdi · Journal of Reports in Pharmaceutical Sciences · 2021
Amal Hari, Ghizlane Echchgadda, Fatima-Azzahra Darkaoui · Frontiers in Plant Science · 2024
D.I. Akinloye, O.S. Sojinu, C.A. Moses · Clinical Nutrition Open Science · 2022
Sanaa Ouzakar, Nadia Skali Senhaji, Abdeltif El Harsal · International Microbiology · 2024
Related research
- Hepatotoxicity and Anaemia Co-morbidity in Treated HIV Patients in Fundong Subdivision in the Northwest Region of Cameroon — shares topic coverage
- Influence of Processing and Storage on the Health Benefits of Sauce Produced from Capsicum spp (Pepper) and Lycopersicum esculentum (Tomato) in CCl4 Induced Hepatotoxic Wistar Rats — shares topic coverage
- Histopathological Changes Associated with Exposure of Male Mice to Profenofos and Chlorpyrifos — shares topic coverage
- Methanolic Extract of Xylopia aethiopica Ameliorates Acetaminophen-Induced Liver Damage in Male Wistar Rats — shares topic coverage
- Phytochemical Analysis and Hepatoprotective Activity of Algerian Santolina chamaecyparissus L. Extracts — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
15
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.