No Evidence for Association of -2518 A/G Promoter Polymorphism of MCP-1 with Risk of Esophageal Cancer in Punjab, North-West India
Vasudha Sambyal, Kamlesh Guleria, Mridu Manjari, Meena Sudan, Manjit Singh Uppal, Neeti Rajan Singh
Journal of Cancer and Tumor International · pp. 1–10 · Published 23 Sep 2017
10.9734/JCTI/2017/36431Abstract
Aim: To investigate the role of MCP-1 -2518 A/G polymorphism in the susceptibility to esophageal cancer in patients from Punjab, North-West India. Methods: In this case-control study, 159 sporadic esophageal cancer patients and 159 age and gender matched controls were included. MCP-1 -2518 A/G promoter polymorphism was analyzed using PCR-RFLP method. Results: The frequencies of GG, GA, and AA genotypes were 43.40%, 47.80% and 8.80% in patients, and 47.17%, 44.65%, 8.18% among the controls respectively. There were no significant differences in genotype and allele frequencies between the patients and controls. Conclusion: In this study, we found no association between MCP-1 -2518 A/G polymorphism and the esophageal cancer risk in North-West Indians.
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