Study of Spermatotoxic Effects Elicited by Bisphenol A Exposure in Male Mus musculus

Abstract

Bisphenol A (BPA) is a common endocrine disrupting chemical that is utilized in the manufacturing of plastic products, shows adverse effects on reproductive health of male. This   study investigates the toxic impacts of BPA on reproductive health of male Swiss albino mice. For this research work, adult male mice weighing about 30±5 grams were divided into three groups (Group I- control, Group II- 55 mg and Group III- 110 mg/ kg body weight) and after the completion of 35 days of treatment, animals were sacrificed and results were made. The findings suggests that both lower and higher dosage of BPA significantly (p<0.001) reduced the sperm count, testicular weight and seminal weight in a dose dependent manner and a significant increase were recorded in the percentage of sperm abnormalities as compared to the control group. Treated group of mice represented remarkable morphological abnormalities such as hookless heads, banana shaped head, round head, broken tail and coiled tails. Thus, the present study concluded that BPA is a toxic chemical widely present in the environment and consumers everyday products that adversely affect the reproductive efficiency through multiple biological processes.