Effect of Passive Transfer of Spleen Cells from Immunized Mice with Hydatid Cyst Antigens on the Growth of Melanoma Cancer in C57/Black Mice
Seyedeh Tala Ramazninia, Seyedeh Maryam Sharafi, Mehran Bahadoran, Fereshteh Jafaee Nodeh, Mehdi Mahmoudzadeh, Hossein Yousofi Darani
Journal of Advances in Medicine and Medical Research · pp. 1–6 · Published 28 Jun 2016
10.9734/BJMMR/2016/26744Abstract
Background: Anticancer effect of hydatid has been shown in previous investigations. However the mechanism of anticancer effects of hydatid cyst has not been clarified. So in this work the effect of spleen cell transfer immunized by the hydatid cyst antigens on melanoma cancer growth in animal model has been investigated. Methods: Spleen cells of mice immunized with hydatid cyst fluid, cyst wall and protoscoleces were transferred to different group of mice and subsequently challenged with melanoma cells. Then the tumor size, tumor growth rate and survival time of mice were compared with those of control groups. Results: Tumor size, tumor growth rate and mice survival time were significantly lower than what observed in control mice. Conclusion: Immune response to hydatid cyst antigens may be involved in Anti-cancer effect of this parasite.
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