Orthokeratinized Odontogenic Cyst:   A Case Series with Clinicopathologic Variation

Mandakini Mandale; Vaishnavi Marge; Jayanti Humbe; Vaishali Nandkhedkar; Savita Wagh; Monika Kajalkar

doi:10.9734/ijrrd/2025/v8i2231

Research Article Open access CC BY 4.0

Orthokeratinized Odontogenic Cyst: A Case Series with Clinicopathologic Variation

Mandakini Mandale, Vaishnavi Marge, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh, Monika Kajalkar

International Journal of Research and Reports in Dentistry · pp. 278–285 · Published 16 Aug 2025

10.9734/ijrrd/2025/v8i2231

Abstract

Orthokeratinized Odontogenic Cyst (OOC) is a rare developmental odontogenic cyst, accounting for approximately 1% of all odontogenic cysts and 10% of all keratinizing odontogenic jaw cysts. The 2017 WHO classification considered OOC as a distinct entity. It is characterized by an Orthokeratinized stratified squamous epithelial lining, a benign nature, and a low recurrence rate of less than 2%. Unlike OKC, OOC lacks aggressive behaviour, showing minimal proliferative activity. Radiologically, OOCs often present with buccolingual expansion and cortical bone destruction, but their growth pattern is less invasive than that of OKC. Due to its favourable prognosis and low recurrence, OOCs should be differentiated from OKC for its appropriate diagnosis & management.

Orthokeratinized odontogenic cyst odontogenic cysts odontogenic keratocyst WHO

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Mandakini Mandale, Vaishnavi Marge, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh, Monika Kajalkar (2025). Orthokeratinized Odontogenic Cyst: A Case Series with Clinicopathologic Variation. International Journal of Research and Reports in Dentistry , 278–285. https://doi.org/10.9734/ijrrd/2025/v8i2231

Affiliations

Mandakini Mandale — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.
Vaishnavi Marge — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.
Jayanti Humbe — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.
Vaishali Nandkhedkar — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.
Savita Wagh — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.
Monika Kajalkar — Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Chhatrapati Sambhajinagar, Maharashtra, India.

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