Pas III Added Donor Platelet Suspensions on Platelet Count Ph and Allergic Transfusion Reactions

Abstract

Aim: Platelet additive solutions (PAS) platelet collection methods, in which less donor plasma is used, are becoming more common in order to reduce the reactions occurring in patients. In our study, we aimed to evaluate the platelet quality in apheresis platelet suspensions (I) collected with PAS-III and to examine the frequencies of other transfusion reactions, especially allergic reactions related to platelet transfusion (II). Materials and Methods: In our study, the results of routine use of apheresis platelet sets between July 2019 and March 2021 were evaluated retrospectively. Results: All of the PAS-III added apheresis platelet concentrates collected in our center, whose quality control was performed in different time periods (100 platelet concentrates) were included. Platelet counts and pH values were examined on the 1st and 5th days of these apheresis platelet concentrates, which were stored in our blood bank at 20-24°C with agitation. In our study, mean platelet counts measured on days 1 and 5 in 65% PAS-III/35% plasma apheresis platelet suspensions were found to be 3.44 x 1011 and 3.0 x 1011, while pH values were determined as 6.83 and 6.62 on days 1 and 5, respectively. Also, no allergic or any other transfusion reaction was detected. Conclusion: In conclusion, in our study, apheresis platelet concentrates suspended in 65% PAS-III/35% donor plasma were associated with (I) better donor comfort and (II) reduction in the frequency and/or severity of transfusion reactions originating from donor plasma.