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Research Article Open access CC BY 4.0

Prevalence, Sensitivity Profile and Resistance of Gram-Positive Bacteria in Wounds to Conventional Antibiotics

Mercy Alabi, Michael Bayode, Ikeoluwa Aina, Jeremiah Adesanya, Oluwaseun Areo

International Journal of Pathogen Research · pp. 9–17 · Published 28 Jun 2021

10.9734/ijpr/2021/v7i230177

Abstract

Aim: The prevalence, sensitivity profile and resistance of Gram-positive bacteria in wounds to commercial antibiotics were ascertained in this study. Place and duration of study: University of Medical Sciences Teaching Hospital, Akure, Nigeria, between January and June 2019. Methodology: Wound swabs sample collection, isolation of bacteria, identification of Gram-positive bacteria isolates and antibiotics sensitivity testing of isolated bacteria were determined employing standard protocols. Result: Three Gram-positive bacteria were isolated and presumptively identified to be S. aureus, S. epidermidis and S. pyogenes. S. aureus had the highest prevalence of 53% followed by S. epidermidis with 42% and S. pyogenes accounting for the least occurrence of 5%. Ninety percent (90%) of ten S. aureus strains were resistant to ciprofloxacin while only 10% had intermediate activity. The least resistance of S. aureus strains was against pefloxacin (40%), while to streptomycin, 87.5% of eight S. epidermidis strains were resistant and 12.5% had intermediate sensitivity. Susceptibility was observed in S. epidermidis against pefloxacin (12.5%) while 50% had intermediate sensitivity and 37.5% were resistant. The highest zone of inhibition of S. epidermidis was observed in strain 7 against pefloxacin (16.00±1.00 mm) and in S. aureus by strain 5 against pefloxacin (16.50±2.50 mm). Conclusion: Pefloxacin-sensitive Staphylococcus and Streptococcus species from wound swabs could become resistant overtime and this calls for incessant vigilance on Gram-positive wound bacteria antibiotic-susceptibility appraisal particularly in an antibiotics-abuse setting.

Antibiotic antibiotics sensitivity Gram-positive bacteria wound swab prevalence

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