Prospective Aspects of Regeneration in Orthopaedics: A Review

Abstract

Musculoskeletal diseases affect millions of people worldwide and are one of the leading causes of long-term pain and physical disability. Traditional treatment methods for promoting healing and repair has always been consider gold standard, But the emergence of new therapeutic approaches aims to regenerate or repair musculoskeletal tissue. The recognition of a regenerative therapy in orthopaedics requires the demonstration of new Bone, Cartilage, ligament, tendons, healing of soft tissues injuries and Overuse conditions like plantar fasciitis or tennis elbow . Regenerative therapy boosts the body’s ability to use its repair systems to heal diseased or damaged cells after a severe injury, or other degenerative condition. A diversity of regenerative strategies have been evaluated, including distraction osteogenesis, bone grafts and bone substitute materials, bone matrix proteins, growth/differentiation factors, combined therapies and, more recently, tissue‐engineering approaches. This review aims to evaluate the current status of the therapies available and to discuss the challenges that must be faced in order to achieve predictable orthopaedic  regeneration in clinical practice.