Hematological and Biochemical Profile of Thalassemia Major Patients: A Comprehensive Analysis from the National Oncology Center, Aden

Abstract

This study aimed to evaluate the hematological and biochemical parameters of 40 patients diagnosed with thalassemia major at the National Oncology Center, Aden, from January to December 2022. The main aim of the present study is to assess Vitamin D and parathyroid hormone levels and some biochemical and hematological investigations and their relation to serum ferritin levels of children with β-thalassemia major who are attending or admitted to the pediatric department in national oncology center-Aden. The demographic data revealed a slight female predominance (52.5%) with a mean age of 10.6 years. Hematological findings indicated significantly low hemoglobin levels (6.72 g/dL) and hematocrit (21.72%). The study also reported a high prevalence of severe serum ferritin levels, with 40% of patients exhibiting values exceeding 4000 ng/L. Biochemical tests showed elevated liver enzymes (GPT, GOT) and abnormal calcium and phosphorus levels. Notably, a significant correlation was observed between serum ferritin and liver enzymes (p < 0.05). Vitamin D deficiency was prevalent in 47.5% of patients. The findings highlight the necessity for regular monitoring and management of hematological and biochemical parameters in thalassemia major patients.