Serum Glucose, Lipid Profile and Oxidative Stress Markers of Salt-induced Metabolic Syndrome Rats Administered Antioxidant Rich Nutraceutical

Abstract

Metabolic syndrome is indeed a high risk condition involving obesity, dyslipidemia, hypertension and diabetes mellitus. The study aim to formulate an antioxidant rich nutraceutical from locally available foodstuff (onion, garlic, ginger, tomato, lemon, palm oil, water melon seeds) and investigate their effects on body weight, serum glucose, lipid profile, insulin and oxidative stress markers in salt induced metabolic syndrome rats. The rats were placed on 8% salt diet for 6 weeks and then supplementation and treatment with nutraceutical and nifedipine in the presence of salt diet for additional 4 weeks. Feeding rats with salt diet for 6 weeks increased body weight of the salt-loaded rats relative to control. Significant (P<0.001) increase in serum blood glucose and lipid profile, and decrease in high density lipoprotein-cholesterol (HDL-C) was observed in salt-loaded rats as compared with control. Supplementation with nutraceutical lowered body weight of the salt-loaded rats and significant (P<0.001) decrease in the serum blood glucose, lipid profile, malonyldialdehyde (MDA), insulin levels, insulin resistance, and increased HDL-C and antioxidant indices was observed. The study suggests that the nutraceuticals are useful in reversing most of the component of metabolic syndrome.