Role of Copper and Zinc in Full-term Pregnancy and İts Effect on Apgar Score
Hayrullah Yazar, Hilal Uslu Yuvacı, Bahri Elmas
Asian Journal of Research in Biochemistry · pp. 16–22 · Published 2 Mar 2023
10.9734/ajrb/2023/v12i1225Abstract
Objective: Our aim in this study; is to determine zinc, copper and copper/zinc ratios in third-trimester pregnant women with a new laboratory method. Methods: In this research conducted on 59 pregnant women in the last trimester, Those diagnosed with preeclampsia, preterm birth, postmaturity, and gestational diabetes were excluded from the study. In pregnant blood serums, zinc and copper levels were studied on fully automatic analyzers with a new method. The new technique kits used in the study are Rel Assay Diagnostics brand. The zinc ion reacted with 5-Br-PAPS and gave an absorbance at a wavelength of 548 nm in direct proportion to the total zinc level. The copper ion reacted with 3,5-DiBr-PAESA and showed absorbance at 572 nm in direct proportion to the total copper level. Zinc and copper measurements were made in this way by the colourimetric method. Additionally, copper/zinc ratios were calculated. In addition, determined the APGAR (Activity-Pulse-Grimace-Appearance-Respiration) score of the babies. Statistical studies of the obtained data were performed at p<0.05 significance level. Results: Zinc and copper parameters; No statistically significant relationship was found in the analyzes performed with gestational age, gestational week, birth weight, APGAR score, gravida and the number of living children (p>0.05). In addition, it was observed that there was no difference in zinc and copper/zinc ratios in the evaluations made according to the gender of the baby (p>0.05). On the other hand, copper levels in pregnant women; were found to be significantly higher in female fetuses (200.72±36.36) than in males (164.17±42.47) (p<0.001). Conclusion: Although the copper values of pregnant women with female fetuses are significantly higher, these results require more comprehensive studies. On the other hand, there is not relationship between zinc, copper and copper/zinc values and APGAR scores.
References (21)
- 1 Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
- 2 Harper's Illustrated Biochemistry
- 3 Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health [DOI]
- 4 The Apgar Score [DOI]
- 5 Intestinal absorption of water-soluble vitamins in health and disease [DOI]
- 6 Elevation of serum copper levels in Alzheimer’s disease [DOI]
- 7 Position of the Academy of Nutrition and Dietetics: Nutrition and Lifestyle for a Healthy Pregnancy Outcome [DOI]
- 8 The Effect of Very Advanced Maternal Age on Maternal and Neonatal Outcomes: A Systematic Review [DOI]
- 9 Lifestyle, Maternal Nutrition and Healthy Pregnancy [DOI]
- 10 Importance of nutrition during pregnancy. Impact on the composition of breast milk [DOI]
- 11 Pregnant Adolescent and Adult Women have Similarly Low intakes of Selected Nutrients [DOI]
- 12 Pregnant women's knowledge and awareness of nutrition [DOI]
- 13 Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome [DOI]
- 14 Kisspeptin in the Prediction of Pregnancy Complications [DOI]
- 15 Study on Reference Range of Zinc, Copper and Copper/Zinc Ratio in Childbearing Women of China [DOI]
- 16 Associations between provider-assigned Apgar score and neonatal race [DOI]
- 17 Myths about nutrition in pregnancy [DOI]
- 18 Diagnosis of Vitamin B 12 Deficiency in Patients with Myeloproliferative Disorders [DOI]
- 19 Serum Copper and Zinc Levels and Urinary Incontinence in Adult Women [DOI]
- 20 Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes [DOI]
- 21 Changes of new coagulation markers in healthy pregnant women and establishment of reference intervals in Changsha. [DOI]
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