A Case-control Study on the Risk of Upper Gastrointestinal Bleeding in Patients Taking Non-steroidal Anti-inflammataory Drugs (NSAIDs) in Mashhad, Iran
Sajjadi Samaneh, Taherzadeh Zhila, Eslami Saeid, Mokhtari Amirmajdi Elham, Khaksari Ali, Foad Faroughi, Ahadi Mitra
Asian Journal of Research and Reports in Gastroenterology · pp. 13–21 · Published 14 Jan 2019
Abstract
Introduction: Gastrointestinal bleeding is one of the most common causes of patient admissions at emergency wards. Despite considering nonsteroidal antiinflammatory drugs (NSAIDs), aspirin and Helicobacter pylori as the leading causes, mortality from gastrointestinal (GI) bleeding is still high. So pattern of NSAID consumption and related conditions may help in preventative behavior. Methods: This case-control study was conducted on 300 patients. Patients were divided into two groups: with and without GI bleeding. Patient's information was extracted using their hospital records and the data eventually was statistically analyzed. Results: The results of this study showed no significant difference between the two groups in terms of age, gender, marital status, distribution of weight, and education level (P>0.05).The frequency of NSAIDs use was significantly higher in patients with gastrointestinal bleeding (P = 0.016) with the most NSAID use as aspirin(32.66%). The prevalence of smoking, using drugs and alcohol consumption was significantly higher in the study group (P <0.05). Conclusion: A history of consuming NSAIDs increases the risk of GI bleeding. The frequency of cigarette, drug, and alcohol consumption in the case study group was significantly higher than that of the control group.
Cited by 0
No indexed citations yet.
Related research
- Effect of Interacting Organic Co-solutes with Enzyme Substrate Complex on the Hydrolysis of Raw Soluble Starch with -amylase: Theory and Experimentation — shares topic coverage
- Anti-ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats — shares topic coverage
- Amelioration of Non-steroidal Anti-inflammatory Drug Induced Gastropathy by Nigella sativa Oil- An Experimental Study — shares topic coverage
- Experimental Evaluation of Analgesic and Antioxidant Effects of Hydromethanolic Extract of Dioscorea dumetorum Tuber — shares topic coverage
- Chemometric Assisted HPLC Method for the Simultaneous Estimation of Aspirin, Atorvastatin and Clopidogrel in Biological Matrix — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.