Severe Weight Loss and Emaciation Following Topiramate Administration
Mohammad Abu-Hegazy, Abdallah M. Almarzoogi, Sultan M. Almarzoogi, Waseem Marei M. Marei
International Neuropsychiatric Disease Journal · pp. 1–4 · Published 6 Sep 2017
10.9734/INDJ/2017/35961Abstract
Topiramate is an antiepileptic drug, used also for prevention of an episodic migraine. Its effects include sodium-channel-blocking activity, enhancement of cerebral GABA concentrations and antagonism of AMPA/kainate receptors, which leads to a decreased glutamate-mediated excitation. It is documented to possess weight reducing properties. It attenuates appetite through mechanisms that remain to be elucidated. Severe weight loss is not reported in the literature. We investigated one patient with severe weight loss (40.2% loss) resulted in emaciation and found that the implicated drug was topiramate. This notion was confirmed when we discontinued the implicated drug (Topiramate) as the patient regained his weight again to the previously recorded levels. Conclusion: Severe weight loss up to emaciation may occur after topiramate administration, Topiramate can be used to counteract the weight gain effect of antipsychotics, long acting topiramate preparation alone or in combination with long acting phentermine can be used to treat morbid obesity.
Cited by 0
No indexed citations yet.
Related research
- Metabolic Syndrome among Healthcare Workers in a Tertiary Hospital in South-South, Nigeria — shares topic coverage
- Dietary Pattern and Prevalence of High Blood Pressure among Adult Traders in Port Harcourt, Nigeria — shares topic coverage
- Impact of the Diet Profile and Alcohol Consumption on Cardiometabolic Risks in Dschang Health District-Cameroon — shares topic coverage
- Gender Specific Predictive Performance and Optimal Threshold of Anthropometric Indices for the Prediction of Hypertension among a Ghanaian Population in Kumasi — shares topic coverage
- Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.