Optimization of Synthesis Process of 4-Methylquinazoline
Juan Liu, Yun Yang, Liangchun Li
International Research Journal of Pure and Applied Chemistry · pp. 1–5 · Published 21 Aug 2017
10.9734/IRJPAC/2017/35918Abstract
4-Methylquinazoline was synthesized with 2-aminoacetophenone and formamide as the starting materials. The reaction conditions, including catalyst, ratio of substrates, temperature and time were optimized. Results showed that the optimal condition were as follows: Catalyst BF3-Et2O, the molar ratio of 2-aminoacetophenone: BF3-Et2O = 1:0.5, the weight ratio of 2-aminoacetophenone: formamide = 1:52, temperature 150°C, and time 6 h. Under the optimal conditions, the yield of the reaction achieved the highest (86%), which are better than the past reports.
Cited by 1
Gandhesiri Satish, Ashok Polu, Laxman Kota · Organic & Biomolecular Chemistry · 2019
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