Study of Expression of P53 in Prostatic Lesions

Abstract

Prostate gland is an accessory gland of the male reproductive system.Prostate begins development from the mesenchymal tissue, surrounding the urogenital sinus in the 3 rd month of gestation. Epithelial buds invaginate from the posterior sinus on either side of verumontanum. Concurrently, Wolffian ducts develop into seminal vesicles, epididymis, Vasdeferens and ejaculatory ducts that are stimulated by fetal testosterone. Histologically all malignant lesions encountered were Conventional Adenocarcinoma of Prostate. The commonest pattern seen was acinar followed bycribriform and fused glandularpattern. Conventional Adenocarcinoma forms the most commontype of prostatic carcinoma and they are moderately differentiated byGleason’s microscopicgrading. Serum Prostate Specific Antigen (PSA) levels increases proportionately with advancing clinical stage. Studies have shownthat serial increase in serum PSA is associated with incidence of occult carcinoma.In the present study, the TURP specimen received was ranged in the volume from 8 to 20cc. Every tissue was carefully examined for the presence of yellow and firm or gray hard areas and necrotic areas. After fixation and processing, 4 -5µ sections were cut and Hematoxylin and Eosin staining was done. In the present study all the benign lesions stained negative except for cases  were the  PSA  value is  more than  >50ng/ml with  p53 IHC and in prostate carcinoma positive indicating epithelial marker positive for prostate gland. In coclusio, the IHC expression of p53 is significantly up- regulated in malignant lesions and have importance in prognostic factors and disease survival.