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Research Article Open access CC BY 3.0

Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

Mogedda E Haiba, Ebtehal S Al-Abdullah, Noha Mohamed Hilmy

Chemical Science International Journal · pp. 203–220 · Published 3 May 2013

10.9734/ACSJ/2013/3452

Abstract

A new series of hydronaphthalene derivatives incorporated into or fused to different five or six membered nitrogen, oxygen, sulpher, heretrocyclic, S- glycosidic or N-glycosidic moieties and other related products had been described. The hydrazine derivative 2 was coupled with bromo-sugar to achieve N-glycosides in presence of acidic medium while, the products 4 and 15 were coupled with different bromo sugar achieving S-glycosides in presence of a basic medium. Moreover, other derivatives carrying different biologically active side chains and hetero cyclic substituents were synthesized starting with 6-methoxy-1-tetralone 1. Also, the X-ray data of compound 13c was studied. The cytotoxicity of some of the newly synthesized compounds was studied to evaluate their in-vitro inhibitory effects against cellular proliferation in human cultured breast carcinoma cell lines. It has been found that the chalcone derivatives 13a-c and their cyclized thiopyrimidine analogues 14a, b appeared to be potent breast carcinoma growth inhibitors comparing to Doxorubicin.  

Tetra and di-hydronaphthalene derivatives imidazole hydrazide thiosemicarbazide quinazoline-thiones thiazolidinone glycosides cytotoxic x- ray

References (23)

  1. 1 New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening [DOI]
  2. 2 Endogenous concentration and subcellular distribution of androgens in normal and malignant human breast tissue.
  3. 3 Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase [DOI]
  4. 4 Synthesis and biological activity of novel antibacterial quinazolines [DOI]
  5. 5 Novel application of multicellular layers culture forin situevaluation of cytotoxicity and penetration of paclitaxel [DOI]
  6. 6 Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase. [DOI]
  7. 7 Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (Afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. [DOI]
  8. 8 Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives [DOI]
  9. 9 Molecular and biochemical characterization of the tetralin degradation pathway in Rhodococcus sp. strain TFB [DOI]
  10. 10 Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1 [DOI]
  11. 11 Metabolism of polycyclic compounds [DOI]
  12. 12 A New General Approach to Enantiomerically Pure Cyclic and Open‐Chain (R)‐ and (S)‐α,α‐Disubstituted α‐Amino Acids [DOI]
  13. 13 Structure–Activity relationships of 6-fluoroquinazolines: dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation [DOI]
  14. 14 Synthesis, Molecular Docking and Preliminary in-Vitro Cytotoxic Evaluation of Some Substituted Tetrahydro-naphthalene (2',3',4',6'-Tetra-O-Acetyl-β-D-Gluco/-Galactopyranosyl) Derivatives [DOI]
  15. 15 Synthesis and Biological Activity of Novel Antibacterial Quinazolines (III). [DOI]
  16. 16 Synthesis and anticancer evaluation of novel tetrahydronaphthalen-6- ylthiazole heterocycles against human HePG2 and MCF7 cell lines
  17. 17 Synthesis of novel tetrahydronaphthalen-2-yl heterocycles for analgesic, anti-inflammatory and antipyretic evaluation.
  18. 18 EFFECT OF NAPHTHOQUINONES ON SCHISTOSOMA MANSONI IN VITRO AND IN VIVO [DOI]
  19. 19 Synthesis of 3,4-dihydro-4-oxoquinazoline derivatives as potential anticonvulsants [DOI]
  20. 20 Synthesis of some tetrahydronaphthyl-1,2,4-triazines of possible schistosomicidal activity.
  21. 21 Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes [DOI]
  22. 22 Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent α-2 antagonism with moderate NE uptake inhibition [DOI]
  23. 23 ChemInform Abstract: A New General Approach to Enantiomerically Pure Cyclic and Open‐Chain ( R)‐ and (S)‐α,α‐Disubstituted α‐Amino Acids. [DOI]

Cited by 3

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