Transdermal Drug Delivery: Microneedles, Their Fabrication and Current Trends in Delivery Methods
Journal of Pharmaceutical Research International · pp. 1–14 · Published 19 Sep 2017
10.9734/JPRI/2017/36164Abstract
The past few decades have seen a tremendous growth in the use of microneedles in the transdermal delivery of therapeutics. This is due to the several advantages that microneedles offer in the delivery of compounds. Therapeutics are delivered in a simple, minimally invasive and painless manner. This has led to the employment of different materials such as silicon and polymer in the fabrication of this device. Also, methods have been introduced in the fabrication of microneedles to meet the high demand this technology raises. This review article is meant to give a foundational knowledge about this rapidly evolving tool with detailed emphasis on their fabrication and delivery methods as well as future prospects of microneedles in the medical industry.
References (22)
- 1 Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery [DOI]
- 2 Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety [DOI]
- 3 Microneedle technologies for (trans)dermal drug and vaccine delivery [DOI]
- 4 Transdermal Delivery of Drugs with Microneedles—Potential and Challenges [DOI]
- 5 Microneedles for intradermal and transdermal drug delivery [DOI]
- 6 Current advances in the fabrication of microneedles for transdermal delivery [DOI]
- 7 Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review [DOI]
- 8 Microneedles permit transdermal delivery of a skin-impermeant medication to humans [DOI]
- 9 In vivo assessment of safety of microneedle arrays in human skin [DOI]
- 10 Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production [DOI]
- 11 Microneedles for drug delivery: trends and progress [DOI]
- 12 Microneedle Coating Techniques for Transdermal Drug Delivery [DOI]
- 13 Transdermal drug delivery: progress and challenges [DOI]
- 14 Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery [DOI]
- 15 Clinical microneedle injection of methyl nicotinate: stratum corneum penetration [DOI]
- 16 Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin [DOI]
- 17 Optimization of square microneedle arrays for increasing drug permeability in skin [DOI]
- 18 Transdermal Delivery of Insulin via Microneedles [DOI]
- 19 Fabrication of a hollow needle structure by dicing, wet etching and metal deposition [DOI]
- 20 Microneedles and transdermal drug delivery [DOI]
- 21 Intradermal Insulin Delivery [DOI]
- 22 Microneedle: an Advanced Technique in Transdermal Drug Delivery System
Cited by 60
Hye-Rin Jeong, Hyesun Jun, Hye-Ran Cha · Micromachines · 2020
Mahmood Razzaghi, Amir Seyfoori, Mohsen Akbari · Advanced Clinical Pharmacy - Research, Development and Practical Applications · 2023
Mahmood Razzaghi, Mohsen Akbari · Expert Opinion on Drug Delivery · 2025
Zhiyuan Ma, Baicheng Li, Jie Peng · Pharmaceutics · 2022
Mahmood Razzaghi · Polymers · 2025
Jae Hwan Jung, Sung Giu Jin · Journal of Pharmaceutical Investigation · 2021
Sanjay Sharma, Ketan Hatware, Prashant Bhadane · Materials Science and Engineering: C · 2019
Mahmood Razzaghi, Joel Alexander Ninan, Mohsen Akbari · Micromachines · 2024
Roshan Dave, Swapnali Shinde, Nisha Kalayil · Micro and Nano Systems Letters · 2024
Mahmood Razzaghi, Hamid Reza Bakhsheshi-Rad · Journal of Manufacturing and Materials Processing · 2026
Showing 20 of 60 known citations — external sources report more than can currently be individually listed.
Related research
- Influence of Silicon on Reduction of Methane Emissions for Sustainable Rice Production — shares topic coverage
- Effect of Silicon Nutrition on Yield, Uptake and Agronomic Efficiency of Paddy in Acid Lateritic Soils of Odisha — shares topic coverage
- Water Stress Alleviation of Roselle Plant by Silicon Treatment Through Some Physiological and Biochemical Responses — shares topic coverage
- Effect of Si with NPK Levels on Growth, Yield and Blast Disease of Aromatic Rice (Oryza sativa L.) in North-West Plain Zone of India — shares topic coverage
- Effect of Soil and Climatic Conditions on Brown Spot Occurrence in Rice Lowland across Four Agro-climatic Zones of Côte d’Ivoire — shares topic coverage
Article metrics
Real usage data collected on this platform.
86
Page views
0
PDF downloads
26
Outbound clicks
60
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.