Synthesis and Studies on Some Spiro and Fused of Quinone Derivatives

Abstract

Some new Spiro β-lactam, Spiro thiazolidine derivatives were synthesized by the reaction of new Schiff bases (5a-c, 8a-c ) with chloroacetyl chloride and/or mercaptoacetic acid to give new Spiro β-lactam (6a-c, 9a-c ) and new Spiro thiazolidinone derivatives (7a-c, 10a-c ) . Also, new fused pyrazolo derivatives (12a-c, 13a-c) fused isoxazolo derivatives (14a-c) and pyrimidine derivatives (15a-c, 16a-c) were synthesized by the reaction of new arylidine derivatives (11a-c) with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea, respectively.