Synthesis of Novel Methylidene Bridged Quinazoline-Isoquinoline Alkaloids
Sherzod N. Zhurakulov, Burkhon Zh. Elmuradov, Valentina I. Vinogradova
Chemical Science International Journal · pp. 1–7 · Published 24 Aug 2015
10.9734/ACSJ/2015/19859Abstract
Interaction of 3-hydroxymethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazolin-9-one (2) with 1H(aryl)-6,7-dimethoxytetrahydroisoquinolines (3a-f) leads to the formation of novel methylidene bridged quinazoline-isoquinoline alkaloids. By results of IR- and 1Н-NMR – spectroscopy are shown that the synthesized products have enamine form and E-configuration.
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