Determination of the Anti-hyperlipidemic Effects of Cissus quadrangularis Ethanolic Extract on High Fat Induced Hyperlipidemic Rat Model

Abstract

The practice of utilizing herbs and herbal remedies to prevent, treat, or cure diseases, as well as to maintain and promote maximum health, is known as herbalism. In certain areas, people may confuse herbal medicine with treatments. Among the leading causes of mortality globally, atherosclerotic cardiovascular disease (ASCVD) and its long-term effects are particularly notable. Adolescents who have atherosclerosis are at progressively higher risk of cardiac events, including heart disease, myocardial infarction (MI), and stroke, throughout later life. This research examined the effects of a Cissus quadrangularis extract on lipid profiles in rats with high-fat-induced hyperlipidemia. When the high fat dosage was 800 and 1200 mg/kg, respectively, the SGPT and SGOT levels in groups 5 and 6 showed statistically significant results (p<0.05). The SGPT clearly demonstrated this. Still, none of the 400, 800, or 1200 mg/kg doses produced statistically significant results, according to the SGOT. However, the SGPT and SGOT levels decreased in a dose-dependent manner. Statistical analysis during the renal function test showed that the doses of urea in groups 5 and 6, which received 800 and 1200 mg/kg, respectively, were substantially different (p<0.05). However, the creatinine analysis did not provide any statistically significant results. Taking into account high-density lipoprotein (HDL) and low-density lipoprotein (LDL), groups 5 and 6 had statistically significant results (p<0.05) in HDL levels. More specifically, groups 5 and 6, given doses of 800 and 1200 mg/kg, respectively, showed statistically significant results. Triglyceride levels in Group 5 differed statistically significantly (p < 0.05). When it came to total cholesterol levels, Group 5, which received a dosage of 800 mg/kg, showed statistically significant results (p<0.05).