Synthesis and Characterization of a Schiff Base Derived from 6-Methylcoumarin and 2-aminophenol and its Complexes Using Cobalt (II) and Copper (II)

Abstract

Schiff bases and their metal complexes has been a subject of research for a long period till date. Various researchers are focusing on synthesis of various Schiff bases with different metal salts to form complexes and their unique properties tried to be identified. The coumarin possess a lot of medicinal values and it was reported that incorporating of metal ion into its structure increases its activity compared to the coumarin based ligand as reported in literature. Such an attempt made here to synthesize a Schiff base from 6-methylcoumarin and 2-aminophenol and its two metal complexes using cobalt and copper (II) chloride salts. Synthesis was confirmed by FTIR and antimicrobial activity of the ligand (Schiff base) and the metal complex were determined by agar well diffusion method against some bacterial and fungal strains. The melting point of the Ligand was 1580C and that of Schiff bases were found to be 2300C and 2640C for Co (II) and Cu (II) respectively. Molar conductance values of Co (II) and Cu (II) complexes were 15.04 and 12.76µScm-1mol-1 respectively. The result from activity revealed an enhanced antimicrobial activity of the metal complexes over their corresponding Schiff bases in a concentrations dependent manner.