Hepatitis C Virus Genetic Diversity and Drug Mutational Analysis in Cameroon: 1992 to 2013
Judith Ndongo Torimiro, Laure Arlette Tchapda, Maurice Boda, Jude Saber Bimela, Dale Netski, Desire Takou, Donald Scot Burke, Ubald Tamoufe, Eitel Mpoudi-Ngole, Henry Namme Luma, Oudou Njoya, Wilfred Fon Mbacham, Nathan Wolfe, Stuart Ray
Microbiology Research Journal International · pp. 1–10 · Published 20 Sep 2016
10.9734/BMRJ/2016/28823Abstract
HCV infection is endemic in Cameroon. A Direct acting agent (DAAs), sofosbuvir that target the HCV non-structural 5B RNA-dependent RNA polymerase (NS5B RdRp) has recently been incorporated into the standard of care in Cameroon but no drug resistance study to this DAA has been reported in Cameroon. From the laboratory, 157 sequences were obtained and 252 downloaded from the Los Alamos HCV Sequence Database, of which 45 were Core (C), 112 were envelope (E1) and 252 were NS5B sequences were characterized by phylogeny. Drug resistance pattern in the NS5B gene was analyzed using the Geno2Pheno HCV 0.92 tool. Genotypes 1, 2 and 4 were identified. Several drug resistance-associated mutations in the NS5B gene that confer susceptibility (S282T (0.4%), and M414T (0.4%), I434M (2.8%), M414L (6.0%), C289L (13.5%) that confer possible resistance as well as (F415Y (41.3%) and V179A (4.0%) of unknown effect on sofosbuvir (SOF) were identified. There is a low level resistance rate to SOF in Cameroon.
Cited by 2
Aristide Mounchili-Njifon, Abdou Fatawou Modiyinji, P. Mbouyap · IJID Regions · 2025
Fabrice Levoa Eteme, Nadege Mafopa Goumkwa, Alliance-Laure Otam · JAC-Antimicrobial Resistance · 2025
Related research
- Molecular Detection of Extended Spectrum Beta-lactamase Resistance in Escherichia coli from Poultry Droppings in Keffi, Nigeria — shares topic coverage
- Antimicrobial Resistance in Primary Health Care Setting: The Prevalence of Multi-Drug Resistant Organisms in Health Centers under the Primary Health Care Corporation PHCC, Qatar — shares topic coverage
- Evaluation of Multi-drug Resistant Bacteria and High Risk of Contamination in Ready to Eat Fruits in Kano Metropolis — shares topic coverage
- Effect of Misuse of Antibiotics on Cytokine Patterns and Antibiogram of Bacteria Isolates from Surgical Site Infection in Benin City, Edo State, Nigeria — shares topic coverage
- Prevalence and Susceptibility Analysis of Carbapenem Resistant Gram-negative Pathogens in Super Specialty Tertiary Care Center, Mumbai, India — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.