Protective Effect of Damiana (Turnera diffusa) against Growth of Ehrlich Ascites Carcinoma in Female Mice

Abstract

Background and Objective: Ehrlich ascites carcinoma (EAC) is primarily derived from a murine mammary adenocarcinoma. It is a common tumor an undifferentiated carcinoma with high transplantable capability, no regression, rapid proliferation, shorter life span, 100% malignancy and also does not have tumor-specific transplantation antigen. The current study aim to study the protective role of damiana against Ehrlich ascites carcinoma (EAC) induced blood, liver and kidney damage in mice. Materials and Methods: A total of 75 female mice were divided into 5 groups the 1st group was control group, 2nd group was damiana group, 3rd group was EAC group, 4th group was pre-treated EAC with damiana, and 5th group was co-treated EAC with damiana. Results: Current results revealed that; EAC induce significant increase in AST, ALT, ALP, urea, creatinine, potassium ions (K+), chloride ions (Cl-), cholesterol, triglyceride and low density lipoprotein-cholesterol (LDL) while EAC induce significant decrease in total proteins, albumin, sodium ion (Na+), calcium ion (Ca2+) and high density lipoprotein-cholesterol (HDL) as compared to control group. Conclusion: Treatment of EAC with damiana as pre-treated or co-treated modeulates this parameters with best results for pretreatment than co-treatments. It could be concluded that; damiana has hepatic and renal protective effect against EAC induced changes in blood.