Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies
Oluwole S. Owojuyigbe, Caleb K. Firempong, Christopher Larbie, Gustav Komlaga, Benjamin O. Emikpe
Journal of Complementary and Alternative Medical Research · pp. 1–10 · Published 24 Mar 2020
10.9734/jocamr/2020/v9i230136Abstract
Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in Hura crepitans stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of Hura crepitans with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of Hura crepitans plant.
Cited by 12
Yu-Cheng Kuo, B. Lawal, Halima Y. Lukman · International Journal of Medical Sciences · 2025
Elise Crossay, Valérie Cristofoli, P. Vásquez-Ocmín · Journal of Pharmaceutical and Biomedical Analysis · 2024
Halima Y. Lukman, Yu-Cheng Kuo, M. Owolabi · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
Elise Crossay, Valérie Jullian, Manon Trinel · Bioorganic & Medicinal Chemistry · 2023
R. Ugbaja, A. O. Simeon, E. I. Ugwor · Grasas y Aceites · 2022
Martha-Yanira Velazquez-González, J. Loya-Olguin, Y. Valdés-García · Veterinary Sciences · 2022
I. Hassan, B. Sa'idu, J. Ishaq · 2020
O. S. Owojuyigbe, C. Firempong, G. Komlaga · 2020
G. C. Ezeh, N. Udeh, C. Ozioko · Notulae Scientia Biologicae · 2021
Maciej Gogulski, Marie Ardois, Julia Grabska · Medycyna Weterynaryjna · 2020
Related research
- Histopathological Effects of Industrial Effluents on Lung Tissues of Wistar Rats — shares topic coverage
- Phytochemical and Antibacterial Properties of Andrographis paniculata (Burn.F.) on Enteric Bacteria Isolated from a Surface Water in Owena, Nigeria — shares topic coverage
- Identification, Molecular Docking and Pharmacokinetic Evaluation of Bioactive Flavonoids from Dennettia tripetala Baker. f. (Annonaceae) Root — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
12
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.