Cell Aging of Mouse Liver as Observed By Microscopic Radioautography

Abstract

“Cell Ageing” means how the cells change due to their aging. The term contains 2 meanings, one how a cell changes when it is isolated from original animals such as in vitro cells in cell culture or tissue culture, while the other means how all the cells of an animal such as mice and rats changes in vivo due to the aging of the individual animal. Our group have been studying the latter changes from the viewpoint of the cell nutrients, the precursors for the macromolecular synthesis such as DNA, RNA, proteins, glucides and lipids, which are incorporated and synthesized into various cells, cell organelles both nuclei and cytoplasm of individual animals. Therefore, this article deals with only the cell aging of animal cells in vivo, how the metabolism, i.e., incorporations and syntheses of respective nutrient precursors in various kinds of cells change due to the ageing of individual experimental animals such as mice and rats by means of microscopic radioautography to localize the RI-labeled precursors. The incorporations and syntheses of various precursors for macromolecules such as DNA, RNA, proteins, glucides, lipids and others in various kinds of cells of various organ in respective organ systems such as skeletal, muscular, circulatory, digestive, respiratory, urinary, reproductive, endocrine, nervous and sensory systems are already published from our laboratory during these 50 years since the late 20C to the early 21C. Among these publications, this paper deals with the cell ageing of the liver of mouse reviewing many papers already published from our laboratory.