Analysis of Thermodynamic Properties of Ranitidine Hydrochloride in Aqueous-sodium Chloride/Sucrose Solutions at 30ºC

Abstract

Ultrasonic velocity (u), density (r), refractive index (n) and relative viscosity (hr) measurements were carried out for ranitidine hydrochloride in aqueous-sodium chloride/sucrose solutions at 30°C in order to understand the effect of electrolyte and non-electrolyte on physicochemical behaviour of aqueous-ranitidine hydrochloride solution. The measured and derived properties such as apparent molar volumes (V2,j), isentropic compressibility (ks), apparent molar isentropic compressibility (kS,2,f) and specific acoustic impedance (Z) have been analyzed in terms of structure and different interactions in studied solutions. The limiting partial molar volumes (V2o,f) of drug have been determined from the Massons relation and standard transfer volume (DtV2o,f) were also computed and interpreted for their sign and magnitude for different systems. The relative viscosity data has been analyzed by the Jones-Dole linear fitting relation and viscosity-A and B coefficients were determined and used to understand the solute-solute and solute-solvent interactions.