Prostaglandins and Thromboxane Status in Patients with Cardiovascular Diseases in Ekiti State, Nigeria
M. F. Asaolu, A. A. Sonuga, S. O. Ajiboye
Asian Journal of Research in Biochemistry · pp. 1–4 · Published 28 Jun 2018
10.9734/ajrb/2018/v2i3487Abstract
Aims: Prostaglandins and Thromboxane A2 are prostanoids, with platelet aggregator and vasoconstrictor properties. This study was carried out to assess the prostaglandins and thromboxane status of patients with cardiovascular diseases in Ekiti State, Nigeria. Study Design: This is a comparative study. Methodology: Two hundred patients with various cardiovascular diseases (Stroke, Ischemic heart disease, Hypertension, Hypertension with diabetes and Hypertension with Obesity) were recruited from Federal Teaching Hospital, Iddo Ekiti and Ekiti State Teaching Hospital, Ado Ekiti. Thirty subjects without cardiovascular diseases were used as a control. Their age range was between 30 and 90 years. Plasma prostaglandin, PGD-2, PGE-1 and thromboxane TXA2 were evaluated in all groups by the use of Enzyme-Linked immunosorbent assay (ELISA). The data obtained was subjected to student t-test and ANOVA. Results: The results showed a significant increase (P>0.05) in the plasma levels of prostaglandin (PGD-2, PGE-1) and thromboxane A2 (TXA2) in all the cardiovascular groups when compared with the control. Plasma levels of TXA2 were found to be significantly higher (P>0.05) in stroke patients when compared with the other type of diseased cardiovascular patients. Conclusion: This study shows that the assessment of plasma prostaglandin and thromboxane levels in cardiovascular disease could be an essential tool in the diagnosis of cardiovascular diseases.
Cited by 0
No indexed citations yet.
Related research
- The Relationship between Upper Extremity Motor Function and Oral Hygiene among Stroke Survivors: Study Protocol for a Mixed-Method Design — shares topic coverage
- Cognitive Recovery Outcome in a 12 Month Quasi-experimental Study Involving Sub-acute Stroke Survivors in Selected Hospitals in Nnewi, Anambra State, Nigeria — shares topic coverage
- Stroke Awareness and Drug Adherence among Adult Hypertensives in a Tertiary Health Care Centre — shares topic coverage
- The Impact of Upper Limb Functioning on Gait Patterns in Individuals with Post-Stroke Hemiplegia — shares topic coverage
- Circadian Variation of Stroke in a Tertiary Level Hospital — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.