Effects of Deionization Water Treated with Different Dose of Aluminum Chloride (AlCl3) on Creatinine and Liver Enzymes of Wistar Rats

Abstract

The experiment was done in Department of Biochemistry and Molecular Biology. Aluminum chloride is used as coagulant for treatment the drinking water in AlMogran Water Treatment Plant, Khartoum State, Sudan. The study aimed at assessing the concentrations of liver enzymes (AST and ALT) and creatinine of Wister rats treated orally with Aluminum chloride by using deionization water. Fifty adults rats (average body weight about 109 g) were divided into five groups (10 male per group) as follows Group one (G1) represented control (without treatment), Group two (G2) received tap water, Group three (G3) received 50 mg/kg/day deionizing water treated with AlCl3, Group four (G4) received 60 mg/kg/day deionizing water treated with dose of AlCl3 and Group five (G5) received 70 mg/kg/day deionizing water treated with dose of AlCl3. The treatments were given orally by gavages and continued daily for 60 days. Then blood sample was collected from each rat and measured for liver enzymes and kidney creatinine. The results showed that AlCl3 had led to a significant increase in liver enzymes and kidney creatinine (P≤ 0.05). In addition histopathology of liver of rats in G4 (60 mg \ kg Al C3) was showed severe necrosis, while the kidney showed packing, dilatation of renal tubules and degeneration compared with control group.