Facile Synthesis and Characterization of New 2,3-Disubstituted Benzimidazole Derivatives
Olayinka O. Ajani, Emmanuel K. Ezeoke, Abiola Edobor-Osoh, Alice O. Ajani
International Research Journal of Pure and Applied Chemistry · pp. 10–21 · Published 8 Feb 2013
10.9734/IRJPAC/2013/2480Abstract
Benzimidazoles are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of five 2-substituted benzimidazole precursors (1a-e) were synthesized via [4 + 1] condensation and imino compound (1f) by simple condensation in the presence of Conc. HCl as catalyst. Synthetic modification of N-1 position was achieved in order to obtain new 5-chloro-2,4-dinitrophenyl bearing 1,2-disubstituted benzimidazole 2a-e and 2f, and 3-chlorobenzyl bearing 1,2-disubstituted benzimidazole 3a-e and 3f in good to excellent yields using a facile approach. The chemical structures of all synthesized compounds were confirmed using spectroscopic means such as UV-visible, IR, Mass spectra, 1H and 13C NMR as well as C, H, N elemental analytical data.
Cited by 0
No indexed citations yet.
Related research
- Anti-Urolithiasis Activity of Selected Plant Extracts by Titrimetry Method and Aggregation Assay — shares topic coverage
- Estimation of Naturl Radioactivity Levels in Some Food Spices Commonly Used in Nigeria and Its Radiological Risks — shares topic coverage
- Structural Characterization Using FT-IR and NMR of Newly Synthesized 1,3-bis(3-formylphenoxymethyl)-2,4,5,6-tetrachlorobenzene and 1,3-bis(3-(2-hydroxyphenyliminomethyl)phenoxymethyl)-2,4,5,6-tetrachlorobenzene — shares topic coverage
- Antibacterial Activity of the Bioactive Fractions of Cyathula uncinulata (Amaranthaceae) — shares topic coverage
- The Fluorescence Spectroscopic Studies on the Interaction of Diltiazem Hydrochloride with Bovine Serum Albumin — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.